Bähr, Mathias, Prof. Dr.

Professor of Neurology

• 1985 MD, University of Tübingen Medical School, Training in Neurology at University Hospitals in Tübingen and Düsseldorf
• DFG and Max Planck Fellow at the Max Planck Institute for Developmental Biology Tübingen and at the Department of Anatomy and Cell Biology, Washington University St.Louis
• Schilling Foundation Professor for Clinical and Experimental Neurology, University of Tübingen
• Since 2001 Director of the Department of Neurology, University of Göttingen

Major Research Interests
Our research examines cellular and molecular mechanisms of neuronal dysfunction and neuronal cell death in neurodegenerative disorders focusing on Parkinson’s disease (PD). In a translational approach we use several models to study pathophysiological cascades, potential biomarkers and develop new therapeutic strategies.
In the Excellence Cluster MBExC we cooperate with several other groups of the Göttingen Campus to determine the role of a-synuclein aggregation for dopaminergic dysfunction and cell death. To that end, we have recently also established new differentiation protocols for iPS cells from idiopathic and genetic PD patients. In all our model systems we use AAV-mediated viral gene transfer to express different disease-or de-/regeneration associated genes as research tools and also as potential therapeutic factors to manipulate the respective molecular events in vitro and in vivo. In parallel, we examine the pathophysiology in PD patients and develop new diagnostic and prognostic biomarkers.
Final aim of our research approaches is to describe in detail the molecular pathophysiology that leads to axonal and neuronal loss and to develop new therapeutic strategies, some of which have already been translated into proof of concept studies in human patients.

Homepage Department/Research Group
https://neurologie.umg.eu
http://www.baehrlab.med.uni-goettingen.de/

ORCID: 0000-0002-9570-1592